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ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion", and describes the disposition of a pharmaceutical compound within an organism. ADME is an abbreviation in pharmacokinetics and pharmacology for "absorption, distribution, metabolism, and excretion", and describes the disposition of a. ADME, which stands for “Absorption, Distribution, Metabolism, Excretion,” is a process by which a drug reaches the target organ in vivo. The ADME service.