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There were 1, differentially methylated genes in the anterior cingulate cortex of mice four weeks after contextual fear conditioning. Where demethylations occur, oxidation of the guanine in the CpG site to form 8-oxo-dG is an important first step. TET1 is a key enzyme involved in demethylating 5mCpG. This initiates the demethylation pathway shown in the second figure in this section.
Altered protein expression in neurons, controlled by 8-oxo-dG-dependent demethylation of CpG sites in gene promoters within neuron DNA, is central to memory formation. From Wikipedia, the free encyclopedia. CAS Number. Interactive image Interactive image. PubChem CID. Chemical formula.
Chemical compound. Bohr July Cancer Research. PMID World J Gastrointest Oncol. PMC Toxicological Sciences. Nucleic Acids Res. Experimental Biology and Medicine. World Journal of Surgical Oncology. Oxid Med Cell Longev. Bibcode : PNAS Redox Signal.
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